Triton-B Catalyzed One Pot Multicomponent Synthesis of Isothiocyanates in Non-Aqueous Medium

Multicomponent one-pot synthesis of highly-functionalized pyrrole-3-carbonitriles in aqueous medium and their computational study.

A one-pot green protocol involving four-components in aqueous medium is developed to synthesize highly-functionalized pyrroles in good yields. Two of the newly synthesized compounds were subjected to in silico analysis on the Pharm Mapper web-server and the human mitogen-activated protein kinase1 (MEK1) enzyme was identified as a potential target protein for these compounds. For target validati...

Mesolite catalyzed one pot synthesis of quinoline-3-carbonitrile derivatives

Natural mesolite type zeolite was collected, modified by sulfuric acid treatment and characterized by using Powder-X ray diffraction (XRD), Scanning electron microscopy (SEM), Energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FT-IR).Temperature programmed ammonia desorption (NH3-TPD), Brunauer-Emmer-Teller (BET) surface area analysis.  Modified dealuminat...

Choline chloride: 2 ZnCl2 catalyzed efficient one-pot regioselective synthesis of dihydrobenzofuro[2,3-b]benzofuran

The reaction of 2-naphthol and also para-substituted phenols with glyoxal in presence of choline chloride: 2 ZnCl2 [ChCl: 2ZnCl2], a deep eutectic solvent (DES), as a green catalyst was studied. The amount of catalyst, solvent type, temperature, and time on the yield of reaction were investigated. It was found that the optimal condition included 10% mol ratio of catalyst (mol percentage of DES ...

Mesolite catalyzed one pot synthesis of quinoline-3-carbonitrile derivatives

Natural mesolite type zeolite was collected, modified by sulfuric acid treatment and characterized by using Powder-X ray diffraction (XRD), Scanning electron microscopy (SEM), Energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FT-IR).Temperature programmed ammonia desorption (NH3-TPD), Brunauer-Emmer-Teller (BET) surface area analysis.  Modified dealuminat...

CuCl2 Catalyzed Solvent-free One Pot Synthesis of Dihydropyrimidinones